Intrinsic factor antibodies are much less sensitive than parietal cell antibodies, but they are much more specific.
2.
However, around 85 % of PA patients have parietal cell antibodies, which means they are a sensitive marker for the disease.
3.
The presence of antibodies to gastric parietal cells and intrinsic factor is common in PA . Parietal cell antibodies are found in other autoimmune disorders and also in up to 10 % of healthy individuals, making the test nonspecific.
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